DealBook: Michael Dell’s Empire in a Buyout Spotlight

The computer empire of Michael S. Dell spreads across a campus of low-slung buildings in Round Rock, Tex.

But his financial empire — estimated at $16 billion — occupies the 21st floor of a dark glass skyscraper on Fifth Avenue in Manhattan.

It is there that MSD Capital, started by Mr. Dell 15 years ago to manage his fortune, has quietly built a reputation as one of the smartest investors on Wall Street. By amassing a prodigious portfolio of stocks, companies, real estate and timberland, Mr. Dell has reduced his exposure to the volatile technology sector and branched out into businesses as diverse as dentistry and landscaping.

Now, Mr. Dell is on the verge of making one of the biggest investments of his life. The 47-year-old billionaire and his private equity backers are locked in talks to acquire Dell, the company he started with $1,000 as a teenager three decades ago, in a leveraged buyout worth more than $20 billion. MSD could play a role in the Dell takeover, according to people briefed on the deal.

The private equity firm Silver Lake has been in negotiations to join with Mr. Dell on a transaction, along with other potential partners like wealthy Asian investors or foreign funds. Mr. Dell would be expected to roll his nearly 16 percent ownership of the company into the buyout, a stake valued at about $3.5 billion. He could also contribute additional personal money as part of the buyout.

That money is managed by MSD, among the more prominent so-called family offices that are set up to handle the personal investments of the wealthy. Others with large family offices include Bill Gates, whose Microsoft wealth financed the firm Cascade Investment, and New York’s mayor, Michael R. Bloomberg, who set up his firm, Willett Advisors, in 2010 to manage his personal and philanthropic assets.

“Some of these family offices are among the world’s most sophisticated investors and have the capital and talent to compete with the largest private equity firms and hedge funds,” said John P. Rompon, managing partner of McNally Capital, which helps structure private equity deals for family offices.

A spokesman for MSD declined to comment for this article. The buyout talks could still fall apart.

In 1998, Mr. Dell, then just 33 years old — and his company’s stock worth three times what it is today — decided to diversify his wealth and set up MSD. He staked the firm with $400 million of his own money, effectively starting his own personal money-management business.

To head the operation, Mr. Dell hired Glenn R. Fuhrman, a managing director at Goldman Sachs, and John C. Phelan, a principal at ESL Investments, the hedge fund run by Edward S. Lampert. He knew both men from his previous dealings with Wall Street. Mr. Fuhrman led a group at Goldman that marketed specialized investments like private equity and real estate to wealthy families like the Dells. And Mr. Dell was an early investor in Mr. Lampert’s fund.

Mr. Fuhrman and Mr. Phelan still run MSD and preside over a staff of more than 100 overseeing Mr. Dell’s billions and the assets in his family foundation. MSD investments include a stock portfolio, with positions in the apparel company PVH, owner of the Calvin Klein and Tommy Hilfiger brands, and DineEquity, the parent of IHOP and Applebee’s.

Among its real estate holdings are the Four Seasons Resort Maui in Hawaii and a stake in the New York-based developer Related Companies.

MSD also has investments in several private businesses, including ValleyCrest, which bills itself as the country’s largest landscape design company, and DentalOne Partners, a collection of dental practices.

Perhaps MSD’s most prominent deal came in 2008, in the middle of the financial crisis, when it joined a consortium that acquired the assets of the collapsed mortgage lender IndyMac Bank from the federal government for about $13.9 billion and renamed it OneWest Bank.

The OneWest purchase has been wildly successful. Steven Mnuchin, a former Goldman executive who led the OneWest deal, has said that the bank is expected to consider an initial public offering this year. An I.P.O. would generate big profits for Mr. Dell and his co-investors, according to people briefed on the deal.

Another arm of MSD makes select investments in outside hedge funds. Mr. Dell invested in the first fund raised by Silver Lake, the technology-focused private equity firm that might now become his partner in taking Dell private.
MSD’s principals have already made tidy fortunes. In 2009, Mr. Fuhrman, 47, paid $26 million for the Park Avenue apartment of the former Lehman Brothers chief executive Richard S. Fuld. Mr. Phelan, 48, and his wife, Amy, a former Dallas Cowboys cheerleader, also live in a Park Avenue co-op and built a home in Aspen, Colo.

Both are influential players on the contemporary art scene, with ARTNews magazine last year naming each of them among the world’s top 200 collectors. MSD, too, has dabbled in the visual arts. In 2010, MSD bought an archive of vintage photos from Magnum, including portraits of Marilyn Monroe and Mahatma Gandhi, and has put the collection on display at the University of Texas, Mr. Dell’s alma mater.

Just as the investment firms Rockefeller & Company (the Rockefellers, diversifying their oil fortune) and Bessemer Trust (the Phippses, using the name of the steelmaking process that formed the basis of their wealth) started out as investment vehicles for a single family, MSD has recently shown signs of morphing into a traditional money management business with clients beside Mr. Dell.

Last year, for the fourth time, an MSD affiliate raised money from outside investors when it collected about $1 billion for a stock-focused hedge fund, MSD Torchlight Partners. A 2010 fund investing in distressed European assets also manages about $1 billion. The Dell family is the anchor investor in each of the funds, according to people briefed on the investments.

MSD has largely remained below the radar, though its name emerged a decade ago in the criminal trial of the technology banker Frank Quattrone on obstruction of justice charges. Prosecutors introduced an e-mail that Mr. Fuhrman sent to Mr. Quattrone during the peak of the dot-com boom in which he pleaded for a large allotment of a popular Internet initial public offering.

“We know this is a tough one, but we wanted to ask for a little help with our Corvis allocation,” Mr. Fuhrman wrote. “We are looking forward to making you our ‘go to’ banker.”

The e-mail, which was not illegal, was meant to show the quid pro quo deals that were believed to have been struck between Mr. Quattrone and corporate chieftains like Mr. Dell — the bankers would give executives hot I.P.O.’s and the executives, in exchange, would hold out the possibility of giving business to the bankers. (Mr. Quattrone’s conviction was reversed on appeal.)

The MSD team has also shown itself to be loyal to its patron in other ways.

On the MSD Web site, in the frequently asked questions section, the firm asks and answers queries like “how many employees do you have” and “what kind of investments do you make.”

In the last question on the list, MSD asks itself, “Do you use Dell computer equipment?” The answer: “Exclusively!”


This post has been revised to reflect the following correction:

Correction: January 18, 2013

An earlier version of this article misstated when an MSD affiliate raised money from outside investors for a hedge fund. It was last year, not earlier this year. The article also misstated which hedge fund and its focus. It was MSD Torchlight Partners, a stock-focused hedge fund, not MSD Energy Partners, an energy-focused hedge fund.

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European regulators ground the Boeing 787 Dreamliner













Boeing 787


European regulators ordered all Boeing 787 Dreamliners grounded Thursday, following the lead of U.S. aviation safety officials.
(David McNew / Getty Images / January 17, 2013)





































































LONDON – European air-safety officials followed their American counterparts’ lead Thursday by grounding Boeing 787 Dreamliner jumbo jets after a series of worrisome incidents aboard the new aircraft.


The European Aviation Safety Agency, or EASA, announced that it was adopting the Federal Aviation Administration’s directive, issued Wednesday, ordering all 787s taken out of service. Jeremie Teahan, a spokesman for the EASA, said the action was taken “to ensure the continuing airworthiness of the European fleet.”


As a practical matter, the decision by European regulators will affect only two 787s being used by the Polish airline LOT. But the move increases pressure on Boeing, which insists that its new passenger jet is safe but has promised to work with the FAA to resolve any concerns.





Doubts about the 787’s safety grew after a fire aboard a plane parked at Boston’s airport and an emergency landing by an All Nippon Airways flight whose crew reported a strange smell and noticed indications of a problem with a lithium-ion battery.


The FAA’s directive was issued less than a week after U.S. transport officials deemed the 787 safe to fly. The agency said that Boeing now had to “address a potential battery fire risk in the 787.”


Teahan said the EASA would “carefully monitor the situation and is prepared to provide any support the FAA may require in their investigation.”


ALSO:


London copter crash kills 2


FAA grounds entire fleet of Boeing 787s


Germany to bring home its gold by 2020







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A Google-a-Day Puzzle for Jan. 17











Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.


SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!


Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.


And now, without further ado, we give you…


TODAY’S PUZZLE:



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Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

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Bigelow directs “Zero Dark Thirty” torture critics to Washington






LOS ANGELES (Reuters) – The director of Oscar-nominated thriller “Zero Dark Thirty” on Wednesday defended the film’s depiction of torture in the hunt for Osama bin Laden, saying criticism would better be directed at the U.S. officials who ordered such policies.


Writing in the Los Angeles Times, Kathryn Bigelow said she personally opposed any use of torture, but said it was a part of the decade-long hunt for the al Qaeda leader that the film could not ignore.






“Those of us who work in the arts know that depiction is not endorsement,” Bigelow wrote of criticism of the movie’s torture scenes from Washington politicians, the media and human rights groups.


“I do wonder if some of the sentiments alternately expressed about the film might be more appropriately directed at those who instituted and ordered these U.S. policies, as opposed to a motion picture that brings the story to the screen,” said Bigelow, who won two Oscars in 2010 for her Iraq war movie “The Hurt Locker.”


“Zero Dark Thirty” was nominated last week for five Academy Awards in February, including best picture, screenplay and actress for Jessica Chastain.


But Bigelow was overlooked in the directing category in a snub that many Hollywood awards watchers attributed to weeks of negative publicity over the film.


A group of senators in December chided distributor Sony Pictures in a letter, calling the film “grossly inaccurate and misleading” for suggesting torture helped the United States capture bin Laden in May 2011.


Actor David Clennon, a member of the Academy of Motion Picture Arts and Sciences that selects Oscar winners, has urged fellow members not vote for the movie, accusing it of promoting torture.


However, in its first week of nationwide release, the movie topped the North American box office on Sunday, taking in $ 24 million.


Bigelow said her personal belief was that “Osama bin Laden was found due to ingenious detective work. Torture was, however, as we all know, employed in the early years of the hunt. That doesn’t mean it was the key to finding bin Laden. It means it is a part of the story we couldn’t ignore. War, obviously, isn’t pretty, and we were not interested in portraying this military action as free of moral consequences.”


“Bin Laden wasn’t defeated by superheroes zooming down from the sky; he was defeated by ordinary Americans who fought bravely even as they sometimes crossed moral lines, who labored greatly and intently, who gave all of themselves in both victory and defeat, in life and in death, for the defense of this nation,” she concluded.


(Reporting By Jill Serjeant; Editing by Doina Chiacu)


Movies News Headlines – Yahoo! News





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Some With Autism Diagnosis Can Recover, Study Finds


Doctors have long believed that disabling autistic disorders last a lifetime, but a new study has found that some children who exhibit signature symptoms of the disorder recover completely.


The study, posted online on Wednesday by the Journal of Child Psychology and Psychiatry, is the largest to date of such extraordinary cases and is likely to alter the way that scientists and parents think and talk about autism, experts said.


Researchers on Wednesday cautioned against false hope. The findings suggest that the so-called autism spectrum contains a small but significant group who make big improvements in behavioral therapy for unknown, perhaps biological reasons, but that most children show much smaller gains. Doctors have no way to predict which children will do well.


Researchers have long known that between 1 and 20 percent of children given an autism diagnosis no longer qualify for one a few years or more later. They have suspected that in most cases the diagnosis was mistaken; the rate of autism diagnosis has ballooned over the past two decades, and some research suggests that it has been loosely applied.


The new study should put some of that skepticism to rest.


“This is the first solid science to address this question of possible recovery, and I think it has big implications,” said Sally Ozonoff of the MIND Institute at the University of California, Davis, who was not involved in the research. “I know many of us as would rather have had our tooth pulled than use the word ‘recover,’ it was so unscientific. Now we can use it, though I think we need to stress that it’s rare.”


She and other experts said the findings strongly supported the value of early diagnosis and treatment.


In the study, a team led by Deborah Fein of the University of Connecticut at Storrs recruited 34 people who had been diagnosed before the age of 5 and no longer had any symptoms. They ranged in age from 8 to 21 years old and early in their development were in the higher-than-average range of the autism spectrum. The team conducted extensive testing of its own, including interviews with parents in some cases, to gauge current social and communication skills.


The debate over whether recovery is possible has simmered for decades and peaked in 1987, when the pioneering autism researcher O. Ivar Lovaas reported that 47 percent of children with the diagnosis showed full recovery after undergoing a therapy he had devised. This therapy, a behavioral approach in which increments of learned skills garner small rewards, is the basis for the most effective approach used today; still, many were skeptical and questioned his definition of recovery.


Dr. Fein and her team used standardized, widely used measures and found no differences between the group of 34 formerly diagnosed people and a group of 34 matched control subjects who had never had a diagnosis.


“They no longer qualified for the diagnosis,” said Dr. Fein, whose co-authors include researchers from Queens University in Kingston, Ontario; Children’s Hospital of Philadelphia; the Institute of Living in Hartford; and the Child Mind Institute in New York. “I want to stress to parents that it’s a minority of kids who are able to do this, and no one should think they somehow missed the boat if they don’t get this outcome.”


On measures of social and communication skills, the recovered group scored significantly better than 44 peers who had a diagnosis of high-functioning autism or Asperger’s syndrome.


Dr. Fein emphasized the importance of behavioral therapy. “These people did not just grow out of their autism,” she said. “I have been treating children for 40 years and never seen improvements like this unless therapists and parents put in years of work.”


The team plans further research to learn more about those who are able to recover. No one knows which ingredients or therapies are most effective, if any, or if there are patterns of behavior or biological markers that predict such success.


“Some children who do well become quite independent as adults but have significant anxiety and depression and are sometimes suicidal,” said Dr. Fred Volkmar, the director of the Child Study Center at the Yale University School of Medicine. There are no studies of this group, he said.


That, because of the new study, is about to change.


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Regulators Around the Globe Ground Boeing 787s


Kyodo News, via Reuters


The 787 that made an emergency landing in Japan on Wednesday. All 137 passengers and crew members were evacuated safely.












Regulators around the globe ordered the grounding of Boeing 787s on Thursday until they could determine what caused a new type of battery to catch fire on two planes in recent days.




The directives in Europe, India and Japan followed an order Wednesday by the U.S. Federal Aviation Administration grounding the planes operated by U.S. carriers.


The decisions are a result of incidents involving a plane that was parked in Boston and one in Japan that had to make an emergency landing Wednesday morning after an alarm warning of smoke in the cockpit.


In Japan on Thursday, the transportation ministry issued a formal order to ground all 787s indefinitely, until concerns over the aircraft’s battery systems are resolved. All Nippon Airways and Japan Airlines had already voluntarily grounded their 787s on Wednesday.


European safety regulators also said they would ground Dreamliners, affecting LOT of Poland, the only carrier that operates the jets in that region. In India, the aviation regulator grounded all six of the 787s operated by the state-owned carrier Air India.


LAN Airlines of Chile said it was following suit, acting in coordination with the Chilean Aeronautical Authority.


And on Thursday, Qatar Airways said it would follow the F.A.A.’s decision and ground its five 787s, effective immediately.


The F.A.A.’s emergency directive, issued Wednesday night, initially applies to United Airlines, the only American carrier using the new plane so far, with six 787s.


Boeing, based in Chicago, has a lot riding on the 787, and its stock dropped nearly 3.4 percent Wednesday to $74.34. The company has outlined ambitious plans to double its production rate to 10 planes a month by the end of 2013. It is also starting to build a stretch version and considering an even larger one after that.


“We are confident the 787 is safe and we stand behind its overall integrity,” Jim McNerney, Boeing’s chief executive, said in a statement.


The grounding — an unusual action for a new plane — focuses on one of the more risky design choices made by Boeing, namely to make extensive use of lithium-ion batteries aboard its airplanes for the first time.


Until now, much of the attention on the 787 was focused on its lighter composite materials and more efficient engines, meant to usher in a new era of more fuel-efficient travel, particularly over long distances. The batteries are part of an electrical system that replaces many mechanical and hydraulic ones that are common in previous jets.


The 787’s problems could jeopardize one of its major features, its ability to fly long distances at a lower cost. The plane is certified to fly 180 minutes from an airport. The U.S. government is unlikely to extend that to 330 minutes, as Boeing has promised, until all problems with the plane have been resolved.


For Boeing, “it’s crucial to get it right,” said Richard L. Aboulafia, an aviation analyst at Teal Group in Fairfax, Virginia. “They’ve got a brief and closing window in which they can convince the public and their flying customers that this is not a problem child.”


The 787 uses two identical lithium-ion batteries, each about one and a half to two times the size of a typical car battery. One battery, in the rear electrical equipment bay near the wings, is used to start the auxiliary power unit, a small engine in the tail that is used most often to provide power for the plane while it is on the ground. The other battery, called the main battery, starts the pilot’s computer displays and serves as a backup for flight systems.


The maker of the 787’s batteries, GS Yuasa of Japan, has declined to comment on the problems.


Boeing has defended the novel use of the batteries and said it had put in place a series of systems meant to prevent overcharging and overheating.


In a conference call last week with reporters, Boeing’s chief engineer for the 787, Mike Sinnett, said that the company had long been aware of possible problems with lithium-ion batteries but that it had built in numerous redundant features to keep any problems with the batteries from threatening the plane in flight. He said that the batteries had not had any problems in 1.3 million hours of flight and that Boeing was trying to understand what had caused the problems.


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Confession could be bad for Lance Armstrong's bank account









Now that Lance Armstrong has finally admitted to using performance-enhancing drugs during his storied athletic career, the shamed cyclist could be pulled into courtrooms around the globe for legal battles with people seeking millions of dollars.

That's one of the many downsides to the confession of a once-adored athlete who for more than a decade not only denied doping but aggressively counterattacked his accusers.

But a significant question remains about whether there is an upside to his coming clean in an interview with Oprah Winfrey scheduled to air later this week.





The confession potentially represents a first step in trying to rebuild his tarnished public image. It might also help in persuading sports officials to reduce his lifetime ban so that the 41-year-old might someday compete in sanctioned triathlons and marathons.

Armstrong faces an uphill climb.

"For him to chart a course to redemption is really complicated and would take a lot of time," said Adam Hanft, a branding and crisis communications strategist. "It's not going to be reversed with a TV appearance."

In his 21/2-hour interview at a downtown Austin, Texas, hotel, Armstrong was forthcoming about the doping allegations that dogged him during a career that included seven Tour de France victories, Winfrey told "CBS This Morning" on Tuesday.

"I don't think 'emotional' begins to describe the intensity or the difficulty he experienced in talking about some of these things," she said, declining to provide further details.

Armstrong has come under increasing pressure in the months since the U.S. Anti-Doping Agency enforced the ban and issued a 1,000-plus-page report that accused him of leading "the most sophisticated, professionalized and successful doping program that sport has ever seen."

With 11 former teammates providing depositions, he was stripped of his Tour championships and lost several big-money sponsors, including Nike, that had made him one of the sporting world's richest endorsers.

Now, Armstrong stands to lose a large chunk of his personal wealth, reported at about $100 million.

His most pressing concern appears to be a federal whistle-blower lawsuit filed by former teammate Floyd Landis, who was stripped of the 2006 Tour de France title for doping. The suit accuses Armstrong of defrauding the U.S. Postal Service, which sponsored his racing team for a number of years.

Armstrong's attorneys have met with government officials to discuss, among other things, how much the Postal Service was actually damaged by his misconduct, according to a person with knowledge of the situation who is not authorized to speak publicly.

During those talks, settlement figures were discussed, the person said.

A lengthy federal investigation into Armstrong and his team was dropped early last year without charges being brought. It remains to be seen whether the criminal statute of limitations has elapsed, but the Department of Justice could join in the civil suit.

The False Claims Act, the basis of whistle-blower suits, carries heavy penalties, including triple damages and fines, said Mike Morse, a Philadelphia-based lawyer who specializes in such cases.

"Violations of the federal False Claims Act can expose him to some really significant monetary damages," Morse said. "There could also be a whole host of private lawsuits."

Reacting to early allegations of Armstrong's doping, a Dallas-based promotional company declined to pay him a $5-million bonus for winning the 2004 Tour de France. He sued and received a $7.5-million settlement.

Now SCA Promotions plans to sue Armstrong to get its money back. "We do expect to file soon," said Jeffrey Dorough, the company's in-house counsel. "We don't know what impact the interview will have until we see it."

The government of South Australia state has said it will seek to recoup several million dollars in appearance fees paid to Armstrong for competing in the Tour Down Under from 2009 through 2011.





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A Google-a-Day Puzzle for Jan. 16











Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.


SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!


Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.


And now, without further ado, we give you…


TODAY’S PUZZLE:



Note: Ad-blocking software may prevent display of the puzzle widget.




Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

Read more by Ken Denmead

Follow @fitzwillie and @wiredgeekdad on Twitter.



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Stuart Scott’s cancer back – but he tweets he’s fighting hard






NEW YORK (TheWrap.com) – ESPN anchor Stuart Scott tweeted that his cancer has returned, but that he’s fighting hard.


How hard? He went from tweeting Monday night about his health to hosting SportsCenter, as if nothing were wrong. As he hosted, he was inundated with supportive tweets.






“Blessed by prayers… I’m back in the Fight,” Scott wrote. “C reared its head again. Chemo evry 2 wks but I’ll still work, still work out..still #LIVESTRONG”


In another tweet, he said that after chemotherapy treatments he goes straight to work out, doing either P90X or mixed martial arts.


Scott was treated for cancer in 2007 after doctors found malignant tissue following an emergency appendectomy. He returned to work at ESPN a month later.


In January 2011, Scott began undergoing chemotherapy after more cancerous tissue was removed. He again returned after a month.


Scott has become a symbol of hope for many who have loved ones fighting the disease or who are fighting it themselves. He traded tweets with some of them after his latest announcement.


He also tweeted Tuesday: “Don’t like using profanity on Twitter but some of my fav well wishes R the good folks who say #F@$ KCancer… I can’t spell it out but I AGREE.”


Celebrity News Headlines – Yahoo! News





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Well: Boosting Your Flu Shot Response

Phys Ed

Gretchen Reynolds on the science of fitness.

As this year’s influenza season continues to take its toll, those procrastinators now hurrying to get a flu shot might wish to know that exercise may amplify the flu vaccine’s effect. And for maximal potency, the exercise should be undertaken at the right time and involve the right dosage of sweat, according to several recent reports.

Flu shots are one of the best ways to lessen the risk of catching the disease. But they are not foolproof. By most estimates, the yearly flu vaccine blocks infection 50 to 70 percent of the time, meaning that some of those being inoculated gain little protection. The more antibodies someone develops, the better their protection against the flu, generally speaking. But for some reason, some people’s immune systems produce fewer antibodies to the influenza virus than others’ do.

Being physically fit has been found in many studies to improve immunity in general and vaccine response in particular. In one notable 2009 experiment, sedentary, elderly adults, a group whose immune systems typically respond weakly to the flu vaccine, began programs of either brisk walking or a balance and stretching routine. After 10 months, the walkers had significantly improved their aerobic fitness and, after receiving flu shots, displayed higher average influenza antibody counts 20 weeks after a flu vaccine than the group who had stretched.

But that experiment involved almost a year of dedicated exercise training, a prospect that is daunting to some people and, in practical terms, not helpful for those who have entered this flu season unfit.

So scientists have begun to wonder whether a single, well-calibrated bout of exercise might similarly strengthen the vaccine’s potency.

To find out, researchers at Iowa State University in Ames recently had young, healthy volunteers, most of them college students, head out for a moderately paced 90-minute jog or bike ride 15 minutes after receiving their flu shot. Other volunteers sat quietly for 90 minutes after their shot. Then the researchers checked for blood levels of influenza antibodies a month later.

Those volunteers who had exercised after being inoculated, it turned out, exhibited “nearly double the antibody response” of the sedentary group, said Marian Kohut, a professor of kinesiology at Iowa State who oversaw the study, which is being prepared for publication. They also had higher blood levels of certain immune system cells that help the body fight off infection.

To test how much exercise really is required, Dr. Kohut and Justus Hallam, a graduate student in her lab, subsequently repeated the study with lab mice. Some of the mice exercised for 90 minutes on a running wheel, while others ran for either half as much time (45 minutes) or twice as much (3 hours) after receiving a flu shot.

Four weeks later, those animals that, like the students, had exercised moderately for 90 minutes displayed the most robust antibody response. The animals that had run for three hours had fewer antibodies; presumably, exercising for too long can dampen the immune response. Interestingly, those that had run for 45 minutes also had a less robust response. “The 90-minute time point appears to be optimal,” Dr. Kohut says.

Unless, that is, you work out before you are inoculated, another set of studies intimates, and use a dumbbell. In those studies, undertaken at the University of Birmingham in England, healthy, adult volunteers lifted weights for 20 minutes several hours before they were scheduled to receive a flu shot, focusing on the arm that would be injected. Specifically, they completed multiple sets of biceps curls and side arm raises, employing a weight that was 85 percent of the maximum they could lift once. Another group did not exercise before their shot.

After four weeks, the researchers checked for influenza antibodies. They found that those who had exercised before the shot generally displayed higher antibody levels, although the effect was muted among the men, who, as a group, had responded to that year’s flu vaccine more robustly than the women had.

Over all, “we think that exercise can help vaccine response by activating parts of the immune system,” said Kate Edwards, now a lecturer at the University of Sydney, and co-author of the weight-training study.

With the biceps curls, she continued, the exercises probably induced inflammation in the arm muscles, which may have primed the immune response there.

As for 90 minutes of jogging or cycling after the shot, it probably sped blood circulation and pumped the vaccine away from the injection site and to other parts of the body, Dr. Kohut said. The exercise probably also goosed the body’s overall immune system, she said, which, in turn, helped exaggerate the vaccine’s effect.

But, she cautions, data about exercise and flu vaccines is incomplete. It is not clear, for instance, whether there is any advantage to exercising before the shot instead of afterward, or vice versa; or whether doing both might provoke the greatest response – or, alternatively, be too much and weaken response.

So for now, she says, the best course of action is to get a flu shot, since any degree of protection is better than none, and, if you can, also schedule a visit to the gym that same day. If nothing else, spending 90 minutes on a stationary bike will make any small twinges in your arm from the shot itself seem pretty insignificant.

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