Jack Klugman, famed for TV role on “The Odd Couple,” dead at 90

LOS ANGELES (Reuters) – Emmy-winning actor Jack Klugman, a versatile, raspy-voiced mainstay of U.S. television during the 1970s and early ’80s through his starring roles in “The Odd Couple” and “Quincy, M.E.,” died on Monday at the age of 90.

Klugman, whose pairing with Tony Randall on “The Odd Couple” created one of television’s most memorable duos, died at his home in the Woodland Hills section of Los Angeles following a period of declining health, according to his son, Adam Klugman.

“He went very suddenly and peacefully … he was there one minute and gone the next,” the actor’s son told Reuters, adding that the elder Klugman had “been in convalescent mode for awhile.”

He said his father had lost his ability to walk and spent much of his time in bed. His wife of four and a half years, Peggy Crosby, former daughter-in-law of the late singer Bing Crosby, was with him when he died, his son said.

In addition to his TV success, Klugman enjoyed a healthy career on the stage as well as in movies and made successful forays into horse breeding and political activism. Not even the loss of a vocal cord to cancer in 1989 could silence him for long.

Klugman gained fame for playing slovenly sports writer Oscar Madison in the sitcom “The Odd Couple” – a role he also had played on Broadway – and then as a crusading coroner in the crime drama “Quincy, M.E.“

“The Odd Couple,” based on Neil Simon’s play about two disparate divorced men forced to share an apartment, ran for five years on the ABC network, starting in 1970, but was never a hit during that time. Only through reruns did Klugman and co-star Randall, who played neat-freak Felix Unger, leave their mark as one of U.S. television’s great sitcom teams.

“We had wonderful respect for one another, we liked working together but we never became friends,” Klugman told the Miami Herald in 2005. “I think that was on account of me. I was withdrawn. I never let anybody get too close.”

It was not until Klugman’s cancer surgery, following years of heavy smoking and throat problems, that a friendship developed with Randall. Klugman had no voice and was glumly resigned to the end of his acting career, but with Randall’s encouragement, he returned to the stage.

They resurrected their “Odd Couple” roles in a 1993 TV movie, and Klugman paid tribute to Randall, who died in 2004, in the memoir “Tony and Me: A Story of Friendship.”

“Quincy, M.E.,” which ran on NBC from 1976 to 1983, saw Klugman assume a heavy behind-the-scenes role. He recalled that he spent 20 hours a day working on the series, and he twice sued its producer, Universal Studios, for a share of the net profits he claimed were owed to him.

LOVE OF HORSES

Horses were perhaps Klugman’s first love – both as a keen gambler starting in his teens and later as a breeder. One of his horses, Jaklin Klugman, finished third in the 1980 Kentucky Derby and earned millions as a stud.

Born Jacob Joachim Klugman on April 27, 1922, he grew up in a tough Philadelphia neighborhood. In 1945 a loan shark was after him due to gambling losses so he fled to Pittsburgh, where he studied drama at Carnegie Tech and worked several jobs to settle his debts.

Two years later in New York, Klugman appeared opposite Henry Fonda in the national stage production of “Mr. Roberts.” In 1960, Klugman received a Tony nomination for his supporting role in the musical “Gypsy.”

In Hollywood, Klugman had notable supporting roles in such films as “12 Angry Men” (1957), “Days of Wine and Roses” (1962) and “Goodbye, Columbus” (1969).

He won the first of three Emmys in 1964 for an appearance on the legal drama “The Defenders.” Klugman and Randall each received Emmy nominations for each of the “Odd Couple” seasons, with Klugman winning in 1971 and 1973 and Randall in 1975.

Klugman also earned four Emmy nominations for NBC’s “Quincy, M.E.” His character, who stepped out of his role as medical examiner to solve murders that flummoxed the Los Angeles police, never had a first name.

Klugman is survived by Crosby, his second wife, whom he married in 2008 after a 20-year courtship; and two sons, Adam and David, from his first marriage to late “Match Game” panelist Brett Somers. Klugman and Somers were separated for more than 30 years of their 54-year marriage, which ended with her death in 2007.

(Reporting by Piya Sinha-Roy; additional reporting and writing by Dean Goodman; Editing by Steve Gorman and Paul Simao)

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Baker's giant thermometer, long on the blink, is taking heat

BAKER — The temperature hit 114 degrees in July, but most folks passing by the "World's Tallest Thermometer" in this Mojave Desert pit stop never knew it.

Once a shimmering beacon of light to Las Vegas-bound drivers heading up Interstate 15 with fat wallets and paper-thin dreams, Baker's 13-story thermometer marks California's last-stop oasis of bathrooms and burger joints before the Nevada state line.

Now it's an eyesore. The pinkish roadside oddity has been on the blink for years. The string of ovals that lighted up in 10-degree increments, the top one also giving the exact temperature, are black and lifeless. The gift shop below is padlocked, its shelves stripped bare.

"It's totally disappointing,'' said Brad Roach, 27, of Los Alamos, N.M., who pulled off the highway on an L.A.-to-Vegas road trip with friends to get a closer look. "It's kind of like the biggest ball of twine," he said, referring to another storied American roadside attraction. "If you're diving by, you have to stop and see it. But there's nothing here.''

The thermometer's demise now serves as a billboard for a town on the brink. A chain link fence surrounds Baker's prized Starbucks — which closed its doors four years ago. Two of the town's three motels are shut. The Royal Hawaiian, which in the best of times aspired to two stars, peeks sadly out onto Baker Boulevard with smashed windows and graffiti-splattered walls.

Part of the blame belongs to the merciless Mojave Desert, where bleached 2-by-4s and cinder blocks are all that remains of gas stations, diners and other ventures that turned to dust along the highways. Part of the decline can be blamed on the recession, which depleted the conga line of vehicles heading to and from Las Vegas that sustains life in this tiny town of 735 on the edge of Death Valley.

Tough times are nothing new in this desert town, born more than century ago as a railroad station serving the borax mines in Death Valley. It was wiped off the map by floods in the '30s and saw its rails pulled up and shipped overseas during World War II. There still isn't a single stoplight in town.

Still, its people persevere. "There's always been work in Baker, but now, instead of one job, people are working two or three,'' said Ronda Tremblay, superintendent of the Baker Valley United School District, which has fewer than 190 students.

Baker has no bank or supermarket, no drugstore or health clinic — those are an hour's drive away, in Barstow.

But some hold out hope for the town and, not surprisingly in these parts, it could come from an unusual place: a spaceship.

The owner of Alien Fresh Jerky, one of the more popular stops on Baker's main drag, has plans to build a three-story, disc-shaped "UFO Hotel." Still in the permitting process, it would tower over the tiny markets, gas stations and restaurants on Baker's main drag. Plans call for a gift shop, cafe and 30-plus rooms. Outside, there would be a pool in the shape of an alien's noggin for guests to take a dip in on hot summer days.

"Forty percent of Americans believe in UFOs. Those are my customers," Luis Ramallo said. "No one has ever seen anything like it.''

A wacky dream? Perhaps. But Ramallo, an electrician who emigrated from Argentina in 1988, has parlayed on those before with great success. His beef jerky store started as a tiny, roadside stand outside of Nevada's Area 51, the top secret U.S. Air Force base that has morphed into the Bethlehem of UFO theology. After Ramallo's oddball enterprise became a hit, he relocated to Baker.

Now his store, on good days, has a line snaking out the door, Ramallo said. He expects even more business once the spaceship hotel opens, which he hopes will be in the next year or two.

"This will be the new big attraction in Baker,'' Ramallo said. "I don't want them to fix the thermometer. I want them to tear it down. It's gone from good to bad to ugly.''

The 134-foot-high thermometer was the brainchild of local businessman Willis Herron, who plunked down $700,000 to build the giant monolith in 1991 next to his Bun Boy Restaurant. The thermometer's 4,900 bulbs glowed so bright that Herron, who lived across the street, had to close his window shades at night.

"For 25 years I've had this dream of putting up the world's tallest thermometer, because people pulling off the freeway in the heat of summer are always making remarks like: 'Whew! It's hotter 'n hell. How hot is it anyway?'" Herron, who died years ago, told the Times in 1991.

The tower's height commemorated the 134-degree record temperature set in nearby Death Valley in 1913.

Shortly after it was finished, the thermometer snapped in two after being buffeted by 70-mph winds. Two years later, the rebuilt thermometer again twisted and swayed as gusts whipped through the valley, popping out light bulbs. The problem was solved when a work crew poured concrete inside the steel tower, anchoring it against the harsh desert wind.

Herron sold the Bun Boy and the giant thermometer to business partner Larry Dabour, owner of the Mad Greek restaurant, another Baker institution. It changed hands again in 2005 when Dabour "liberated" himself from the thermometer, Bun Boy and some other enterprises he owned.

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A Google-a-Day Puzzle for Dec. 24

Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.

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TODAY’S PUZZLE:

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Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

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Bethenny Frankel and husband of 2 years separating

LOS ANGELES (AP) — Bethenny Frankel and husband Jason Hoppy are separating.

The 42-year-old TV personality, chef, author and entrepreneur told The Associated Press Sunday that the split brings her “great sadness.”

“This was an extremely difficult decision that as a woman and a mother, I have to accept as the best choice for our family,” Frankel said. “We have love and respect for one another and will continue to amicably co-parent our daughter who is and will always remain our first priority. This is an immensely painful and heartbreaking time for us.”

Frankel and Hoppy were married in 2010 and have a daughter, Bryn, who was born that same year. The couple’s courtship and marriage were documented in two reality series, “Bethenny Getting Married?” and “Bethenny Ever After…” Frankel gained fame as a star of “The Real Housewives of New York City.” Since her stint on the Bravo show, she has written four books, released a fitness video and founded her Skinnygirl line of cocktails, shapewear and nutritional supplements.

She launched a talk show, “Bethenny,” over the summer that is set to air nationally on Fox stations in 2013.

___

AP Entertainment Writer Sandy Cohen is on Twitter: www.twitter.com/APSandy .

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N.Y.U. and Others Offer Shorter Courses Through Medical School

Training to become a doctor takes so long that just the time invested has become, to many, emblematic of the gravity and prestige of the profession.

But now one of the nation’s premier medical schools, New York University, and a few others around the United States are challenging that equation by offering a small percentage of students the chance to finish early, in three years instead of the traditional four.

Administrators at N.Y.U. say they can make the change without compromising quality, by eliminating redundancies in their science curriculum, getting students into clinical training more quickly and adding some extra class time in the summer.

Not only, they say, will those doctors be able to hang out their shingles to practice earlier, but they will save a quarter of the cost of medical school — $49,560 a year in tuition and fees at N.Y.U., and even more when room, board, books, supplies and other expenses are added in.

“We’re confident that our three-year students are going to get the same depth and core knowledge, that we’re not going to turn it into a trade school,” said Dr. Steven Abramson, vice dean for education, faculty and academic affairs at N.Y.U. School of Medicine.

At this point, the effort involves a small number of students at three medical schools: about 16 incoming students at N.Y.U., or about 10 percent of next year’s entering class; 9 at Texas Tech Health Science Center School of Medicine; and even fewer, for now, at Mercer University School of Medicine’s campus in Savannah, Ga. A similar trial at Louisiana State University has been delayed because of budget constraints.

But Dr. Steven Berk, the dean at Texas Tech, said that 10 or 15 other schools across the country had expressed interest in what his university was doing, and the deans of all three schools say that if the approach works, they will extend the option to larger numbers of students.

“You’re going to see this kind of three-year pathway become very prominent across the country,” Dr. Abramson predicted.

The deans say that getting students out the door more quickly will accomplish several goals. By speeding up production of physicians, they say, it could eventually dampen a looming doctor shortage, although the number of doctors would not increase unless the schools enrolled more students in the future.

The three-year program would also curtail student debt, which now averages $150,000 by graduation, and by doing so, persuade more students to go into shortage areas like pediatrics and internal medicine, rather than more lucrative specialties like dermatology.

The idea was supported by Dr. Ezekiel J. Emanuel, a former health adviser to President Obama, and a colleague, Victor R. Fuchs. In an editorial in the Journal of the American Medical Association in March, they said there was “substantial waste” in the nation’s medical education. “Years of training have been added without evidence that they enhance clinical skills or the quality of care,” they wrote. They suggested that the 14 years of college, medical school, residency and fellowship that it now takes to train a subspecialty physician could be reduced by 30 percent, to 10 years.

That opinion, however, is not universally held. Other experts say that a three-year medical program would deprive students of the time they need to delve deeply into their subjects, to consolidate their learning and to reach the level of maturity they need to begin practicing, while adding even more pressure to a stressful academic environment.

“The downside is that you are really tired,” said Dr. Dan Hunt, co-secretary of the Liaison Committee on Medical Education, the accrediting agency for medical schools in the United States and Canada. But because accreditation standards do not dictate the fine points of curriculum, the committee has approved N.Y.U.’s proposal, which exceeds by five weeks its requirement that schools provide at least 130 weeks of medical education.

The medical school is going ahead with its three-year program despite the damage from Hurricane Sandy, which forced NYU Langone Medical Center to evacuate more than 300 patients at the height of the storm and temporarily shut down three of its four main teaching hospitals.

Dr. Abramson of N.Y.U. said that postgraduate training, which typically includes three years in a hospital residency, and often fellowships after that, made it unnecessary to try to cram everything into the medical school years. Students in the three-year program will have to take eight weeks of class before entering medical school, and stay in the top half of their class academically. Those who do not meet the standards will revert to the four-year program.

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Gun Makers Based in Connecticut Form a Potent Lobby

Gun owners packed a hearing room in the Connecticut capital, vowing to oppose a bill that would require new markers on guns so that they are easier to trace.

One after another, they testified that the technology, called microstamping, was flawed and would increase the cost of guns.

But the witness who commanded the most attention in Hartford that day in 2009 was a representative of one of Connecticut’s major employers: the Colt Manufacturing Company, the gun maker.

The Colt executive, Carlton S. Chen, said the company would seriously consider leaving the state if the bill became law. “You would think that the Connecticut government would be in support of our industry,” Mr. Chen said.

Soon, Connecticut lawmakers shelved the bill; they have declined to take it up since. Now, in the aftermath of the school massacre in Newtown, the lawmakers are formulating new gun-control measures, saying the state must serve as a national model.

But the failed effort to enact the microstamping measure shows how difficult the climate has been for gun control in state capitals. The firearm companies have played an important role in defeating these measures by repeatedly warning that they will close factories and move jobs if new state regulations are approved.

The companies have issued such threats in several states, especially in the Northeast, where gun control is more popular. But their views have particular resonance in Connecticut, a cradle of the American gun industry.

Like manufacturing in Connecticut over all, the state’s gun industry is not as robust as it once was. Still, Connecticut remains the seventh-largest producer of firearms in the country, according to federal data.

Colt, based in Connecticut since the 1800s, employs roughly 900 people in the state. Two other major gun companies, Sturm, Ruger & Company and Mossberg & Sons, are also based in the state. In all, the industry employs about 2,000 people in Connecticut, company officials said.

Gun-control advocates have long viewed Hartford, the capital, as hospitable terrain, because Connecticut is a relatively liberal state and already has more gun restrictions than most. Democrats control both houses of the legislature.

Yet lawmakers in Hartford did more than shelve the microstamping bill in 2009. They also declined to push a bill last year that would have banned high-capacity ammunition magazines — the very accessory used by Adam Lanza to kill 26 people, including 20 children, at Sandy Hook Elementary School in Newtown.

In several states, the gun companies have enlisted unions that represent gun workers, mindful that Democratic lawmakers who might otherwise back gun control also have close ties to labor.

In Connecticut, the United Automobile Workers, which represents Colt workers, has testified against restrictions. The union’s arguments were bolstered last year when Marlin Firearms, a leading manufacturer of rifles, closed a factory in Connecticut that employed more than 200 people. Marlin cited economic pressures, not gun regulation, for the decision, but representatives of the gun industry have said the combination of the two factors could spur others to move.

State law significantly restricts the ability of corporations to make political donations in Connecticut. Employees of Connecticut gun companies have contributed several thousand dollars in total in recent years to state candidates, mostly Republicans, according to an analysis of state records.

Financially, the gun companies and their employees in Connecticut have exerted influence by donating to national groups, especially the National Rifle Association, which have in turn helped Connecticut gun rights groups, according to interviews and financial records.

But it appears that in Hartford, the companies are relying largely on economic arguments.

Their strategy has been led by the industry’s trade group, the National Shooting Sports Foundation, which happens to have its national headquarters in Newtown, a few miles from the site of the shootings.

When Connecticut lawmakers held a hearing in 2011 on the measure to ban high-capacity ammunition magazines, the director of government regulations for the foundation, Jake McGuigan, opened his testimony with some statistics.

Mr. McGuigan told lawmakers that the state’s gun companies contributed $1.3 billion to the Connecticut economy, through their own operations and those of their suppliers.

“Each year, they get courted by other firearm-friendly states, like Idaho, Virginia, North Carolina,” Mr. McGuigan said. He later added, “It’s not an idle threat.”

The federation and Colt have declined to comment on gun-control legislation since the school killings.

“Our hearts go out to our fellow Connecticut residents who have suffered such unimaginable loss,” Colt said in a statement. “We do not believe it is appropriate to make further public statements at this very emotional time.”

Gun-control advocates in Hartford said the gun companies’ strategy was shrewd because it allowed Democratic lawmakers to oppose new regulations while proclaiming that they had not bowed to the National Rifle Association.

Michael Moss and Griff Palmer contributed reporting.

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Richard Adams dies at 65; gay marriage pioneer

Thirty-seven years ago, Richard Adams made history when he and his partner of four years, Anthony Sullivan, became one of the first gay couples in the country to be granted a marriage license. It happened in Boulder, Colo., where a liberal county clerk issued licenses to six same-sex couples in the spring of 1975.

Adams had hoped to use his marriage to secure permanent residency in the United States for Sullivan, an Australian who had been in the country on a limited visa and was facing deportation.

But Colorado's attorney general declared the Boulder marriages invalid. Several months later, Adams and Sullivan received a letter from the Immigration and Naturalization Service that denied Sullivan's petition for resident status in terms that left no doubt about the reason:

"You have failed to establish that a bona fide marital relationship can exist between two faggots," the notification read.

Adams, who later filed the first federal lawsuit demanding recognition of same-sex marriages, died Monday at his home in Hollywood after a brief illness, said his attorney, Lavi Soloway. He was 65.

Soloway described Adams and Sullivan as "pioneers who stood up and fought for something nobody at that time conceived of as a right, the right of gay couples to be married.

"Attitudes at the time were not supportive, to put it mildly," Soloway said. "They went on the Donahue show and people in the audience said some pretty nasty things. But they withstood it all because they felt it was important to speak out."

Born in Manila on March 9, 1947, Adams immigrated to the U.S. with his family when he was 12. He grew up in Long Prairie, Minn., studied liberal arts at the University of Minnesota and became a naturalized U.S. citizen in 1968.

By 1971 he was working in Los Angeles, where he met Sullivan and fell in love.

Four years later, the two men heard about Boulder County Clerk Clela Rorex: She had decided to issue marriage licenses to gay couples after the Boulder district attorney's office advised her that nothing in state law explicitly prohibited it.

On April 21, 1975, they obtained their license and exchanged marriage vows at the First Unitarian Church of Denver.

The Boulder marriages attracted national media attention, including an article in the New York Times that called Colorado "a mini-Nevada for homosexual couples." Rorex received obscene phone calls, as well as a visit from a cowboy who protested by demanding to marry his horse. (Rorex said she turned him down because the 8-year-old mare was underage.)

After their marriage, Adams and Sullivan filed a petition with the INS seeking permanent residency for Sullivan as the spouse of a U.S. citizen. In November 1975, they received the immigration agency's derogatory letter and lodged a formal protest. Officials reissued the denial notice without the word "faggots."

They took the agency to court in 1979, challenging the constitutionality of the denial. A federal district judge in Los Angeles upheld the INS decision, and Adams and Sullivan lost subsequent appeals.

In a second lawsuit, the couple argued that Sullivan's deportation after an eight-year relationship with Adams would constitute an "extreme hardship." In 1985 a three-judge panel of the U.S. 9th Circuit Court of Appeals rejected the hardship argument and opened the way for Sullivan to be sent back to Australia.

Because Australia had already turned down Adams' request for residency in that country, the couple decided the only way they could stay together was to leave the U.S. In 1985, they flew to Britain and drifted through Europe for the next year.

"It was the most difficult period because I had to leave my family as well as give up my job of 18 1/2 years. It was almost like death," Adams said in "Limited Partnership," a documentary scheduled for release next year.

The pair ended their self-imposed exile after a year and came home. They lived quietly in Los Angeles to avoid drawing the attention of immigration officials, but in recent years began to appear at rallies supporting same-sex marriage, Soloway said.

They were encouraged by new guidelines issued by the Obama administration this fall instructing immigration officials to stop deporting foreigners in long-standing same-sex relationships with U.S. citizens.

Although the policy change came more than three decades after Adams and Sullivan raised the issue, it gave Adams "a sense of vindication," Soloway said.

The day before he died, Sullivan told him that the most important victory was that they were able to remain a couple.

"Richard looked at me," Sullivan told Soloway, "and said, 'Yeah, you're right. We've won.'"

Adams, who was an administrator for a law firm until his retirement in 2010, is survived by Sullivan; his mother, Elenita; sisters Stella, Kathy, Julie and Tammie; and a brother, Tony.

elaine.woo@latimes.com

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A Google-a-Day Puzzle for Dec. 23

Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.

SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!

Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.

And now, without further ado, we give you…

TODAY’S PUZZLE:

Note: Ad-blocking software may prevent display of the puzzle widget.

Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

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Follow @fitzwillie and @wiredgeekdad on Twitter.

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Country singer Tate Stevens wins Fox’s ‘X Factor’

NEW YORK (AP) — Tate Stevens, who was mentored by music exec L.A. Reid on the second season of “The X Factor,” has won the Fox singing competition.

The 37-year-old country singer from Belton, Mo., beat runner-up Carly Rose Sonenclar, a 13-year-old schoolgirl from Westchester, N.Y., and teenage girl group Fifth Harmony on the finale that aired live Thursday night.

Stevens wins a $ 5 million recording contract.

More than 35 million votes were cast by viewers after Wednesday’s performance show.

Besides Reid, judges this season included Demi Lovato, Britney Spears and series creator Simon Cowell.

Thursday’s show was also the grand finale for Reid. Earlier this month, he said he wouldn’t be returning to “The X Factor” next year. No replacement has been announced.

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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